"Adapted from BMJ 23 August 2025
The UK drug regulator has approved the first immunotherapy to be licenced to delay the progression of type one diabetes in patients with the early stage of the disease.
MHRA says that teplizumab (Tzield) manufactured by Sanofi, can be given to children over aged 8 and adults who have stage 2 of the disease and are at high risk of progressing to stage 3. At stage 3 blood sugars are raised and usually symptomatic.
If the condition can be detected at stage 2, a 14 day course of daily infusions can delay the onset of symptomatic type one diabetes by an average of three years. It works by binding to certain immune cells and may deactivate those cells that attack insulin producing cells, while increasing the cells that moderate the immune response.
NICE is determining the cost effectiveness of the programme and will decide if it should be rolled out in the NHS. The final report has not yet been published but draft guidance as of January 2026 indicates that it will not be rolled out in the NHS.
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Dr Katharine Morrison comment: This article was published in September 2025 following approval made by the MHRA in August. So far I’ve heard nothing as to whether this drug has been approved by NICE or not. NICE is very keen on value for money. Apart from that, an important aspect is how clinicians are meant to identify those individuals who are on the cusp of developing symptomatic diabetes but who don’t yet know it. Siblings of Type Ones are at high risk (1 in 20 as far as I remember) and children of Type One men (1 in 3). I would imagine that one strategy would be monthly to three monthly finger prick blood sugar tests for those at risk over the age of 8. Time will tell."
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The European Commission has approved Teizeild, the European brand name for the immunotherapy teplizumab, for use in people with stage 2 type 1 diabetes (T1D). This marks an important step forward in efforts to delay the progression of the condition.
19 comments:
I can't speak to any of this because I no nothing about type one. Sounds like you're happy though. Groovy.
...creative scientists come up with fabulous ideas.
That's very interesting and encouraging - they keep making progress! I do wonder how many cases are found that early. Most that I know are found when it would be too late. Still a good thing...
Gracias por la información. Te mando un beso.
Immunotherapy sounds wonderful let's hope! -Christine cmlk79.blogspot.com
Dear Jan, thank you so much for sharing this ❤️
Thank you for this post and information, Jan.
God bless you.
That's good news for your country, Jan, not yet approved here I believe.
Bom dia Jam. Obrigado por compartilhar uma matéria muitos importante. Grande abraço do Brasil.
Hello,
I am glad to see the research being done, anything to help with this disease is welcome. Take care, enjoy your day!
The advances in medicine are such an incredible boon for us... just think back a few decades to what couldn't be cured back then... I don't even want to think back centuries...
Hugs
Investing- thanks for sharing this newsworthy info.
They are making great strides in diabetes.
This is amazing news for type 1. I hope the cost will be affordable. Two of my brother were and are type 1. My youngest brother passed awhile back from complications. Thanks for this info.
Interesting. Could help a lot of people.
This is the first of its kind
Immunotherapy is not without its side effects..I had not heard about this..Hopeful for sure..
Wow it is just amazing what they come up with now, hope it helps people!
Muy interesante todo. Besos.
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